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PURPOSE 2: Could an Investigational Twice-a-Year Injection Prevent HIV?

Our team of clinical scientists are evaluating an investigational PrEP (pre-exposure prophylaxis) medicine, lenacapavir, to see if it helps to reduce the chance of getting HIV through sex.

Some participants in the study will receive the investigational medicine, which is given as an injection under the skin once every 6 months. Other participants in the study will receive daily emtricitabine/​tenofovir disoproxil fumarate (also known as F/TDF or Truvada®) taken by mouth. The active drug you receive may be lenacapavir (2 out of 3 chance) or F/TDF (1 out of 3 chance).

Do you qualify?

What Does the Study Involve?

The first part of the study is a single visit where you will get an HIV test and other lab tests.

If you do not have HIV and meet the other eligibility criteria, you can choose to participate in the second part of the study.

If you are confirmed to have HIV, we will link you to HIV care in your community.

Everyone who enrolls in the second part of the study will receive a daily pill and an injection given every 6 months.

Of the injection and the pill, one will be the active drug and one will be a placebo.

The second part of the study will last for at least 1 year and up to 3 years.

The visits are 4-13 weeks apart, with 4-8 visits per year.

  • Which drug you receive will be determined by chance
  • The active drug you receive may be lenacapavir (2 out of 3 chance) or F/TDF (1 out of 3 chance)
  • Neither you nor the study doctor will know which medication is active and which is placebo
  • When the first part of the study is over, you will find out which active drug you were taking, and you may have the option to enroll in an extension phase where everyone receives lenacapavir

More information about the PURPOSE 2 study can also be found at clinicaltrials.gov.

Learn more about PrEP
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Why Participate?

Participants may receive study drug and monitoring from a local study doctor at no cost.

Another reason could be a desire to support change in how clinical trials are done so that inclusion becomes the standard, not a rarity.

Whatever your reason, the time to join is now.

Do you qualify?
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PURPOSE 2 Questionnaire

Thank you for your interest in participating in the PURPOSE 2 study.

Your privacy matters to us. Note that your answers will only be used to let you know whether or not you qualify, and will not be stored or tracked in any way.

*If you are 16 or 17 years old, please contact your local clinical trial site and learn about their requirements.